Dosage recommendations for Fenbendazole

Fenbendazole’s daily dosage varies according to the patient’s condition and additionally prescribed drugs and/or chemotherapy.

Guide on dosage:

NB: Ensure that you consult a professional licensed medical practitioner with the right attitude and experience in the field of traditional chemotherapeutic and combinatorial (alternative) cancer treatment and experience in medication reconciliation to proscribe negative effects when ingesting numerous drugs/chemicals together. This is very important when you wish to combine chemotherapy, natural products, nutraceuticals, additional supplements, or other pharmaceuticals unrelated to treatment in a synergistic combination with Fenbendazole and also to be sure whether you should take Fenbendazole.

Store Fenbendazole at a temperature of fewer than 25 degrees Celsius, do not expose it to the sun. The same goes for tablets, powder, or capsules.

Understanding toxicity level, metabolism, and possible side effects of Fenbendazole

Toxicity, genotoxicity, and carcinogenicity

It’s not easy to ascertain what negative side effects a normal or high dose of Fenbendazole may cause for humans. This is because it was not originally designed for humans and it hasn’t been used by humans at any point in the past.It’s even more difficult to predict these effects when Fenbendazole is being combined with other drugs.

Fenbendazole, when taken alone,has very little acute toxicity when consumed orally (measured in rodents). There is no determined acute oral exposure limit. This could mean the acute toxicity limit is above 5000mg per kilogram of body weight.

Judging by human data, 500mg per person seems to be mild with no negative effects. Also, it was noted that a single dosage of up to 2,000mg per person didn’t cause any negative reaction.

Some in vitro and in vivo genotoxicity tests performed with the European Medicine Agency involved and slightly responsible, Showed that Febendazole is non-genotoxic.

Evidence found in a 2-year study in mice showed carcinogenicity.

Information was retrieved from (32) concerning genotoxicity, carcinogenicity, and toxicity.

Known side effects:

Some known side effects include:

• Jaundice (very rare)
• Diarrhea (rare)
• Skin itching (very rare)
• Vomiting (rare)
• injury (extremely rare)

Metabolism

After ingesting Fenbendazole, the drug is transformed through two processes in the body namely Oxidation and hydroxylation.

The first process takes place with the aid of liver enzymes – CYP2J2 and CTP2C19. This process hydroxylates Fenbendazole to create a new metabolite; hydroxytenbendazole.

The second process is the oxidation of the sulfide group. This is catalyzed in the liver by the enzymes CYP3A and flavin-containing monooxygenase. As a result, a new compound forms – oxfendazole (which also displays anticancer and anthelmintic properties)

In the second process, the sulfide group undergoes oxidation. The enzyme CYP3A and flavin-containing monooxygenasecatalyze the oxidatedsulfide group in the liver. At the end of the catalyzations, a new compound is formed; Oxfendazole (which has been found to possess anticancer and anthelmintic characteristics.

This process interestingly reveals that Fenbendazole is a drug and a prodrug at the same time considering how it was able to create another active medication.

Due to the bioavailability of Fenbendazole powder, it is not completely converted to its metabolites. We are only able to absorb a small number of Fenben via the gastrointestinal tract. Eventually, Fenbendazole and others like Oxfendazole and hydro-fenbendazole are passed out through the anus.

Note that one of the enzymes involved in metabolizing Fenbendazole CTP2C19 is the same enzyme involved in the metabolism of such drugs asastemizole,mesoridazine, apixaban, tamoxifen, ebasite, cyclosporine, and thioridazine

Before you chose to take one or more of these drugs together, with a larger dosage of Fenbendazole, make sure you contact your doctor for more information and guidance regarding the connection between Febendazole and the other drugs. Try to understand the likelihood of a side effect and the possible elevated.

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