She and her husband Jim Toth, along with a slew of other well-intentioned celebrities, appeared during Saturday’s hour-long Stand Up To Cancer telethon.
The 45-year-old Academy Award-winner was seen just outside Hotel Bel Air in a pair of blue drawstring pants and a white v-neck t-shirt.
Great cause: Reese Witherspoon, 45, was hard at work when she was spotted leaving the Bel Air Hotel ahead of Stand Up To Cancer telethon
Seemingly in 11th hour prep mode, the Oscar-winning actress also wore white sneakers and had her long blonde locks pulled back off her face and into a bun.
She concealed her eyes with a pair of black sunglasses and fastened several chains around her neck.
And with COVID-19 on another surge in recent months, the mother of three made sure to wear a protective mask over her mouth and nose whenever she was in the vicinity of others in and outside of the hotel.
Casual before glamorous: The Oscar-winning actress kept it casual in blue drawstring pants and a white t-shirt before slipping into a more glamorous ensemble for the televised event, which helps raise money for cancer awareness and research
Non-profit work: Witherspoon and husband Jim Toth donated their time to Stand Up To Cancer as co-executive producers for the hourlong televised event on Saturday, August 21
The hourlong special is being hosted by Modern Family alum Sofia Vergara, Black-ish star Anthony Anderson and the husband-and-wife duo of comedian Ken Jeong and Tran Ho.
SU2C co-founder and special guest Katie Couric will also appear, and there will be performances from Alabama Shakes frontwoman Brittany Howard and Common with Stevie Wonder.
Some of the celebrity guests include Matthew McConaughey, Chandra Wilson, Kate del Castillo, Jennifer Garner, MJ Rodriquez, Tony Hale, Deon Cole, Cecily Strong, Max Greenfield.
Working the phones and internet: On Friday, Witherspoon took to Instagram to promote the telethon with calls to celebrities donating their time to the event
Funny: The actress called comedian Ken Jeong, who will take part in the charity telethon and show as co-hosts with his wife Tran Ho
An 11-year-old boy with leukemia will be among the families directly affected by the disease who will have their stories told during the event, which raises money for cancer research.
Stand Up To Cancer will be shown commercial-free on dozens of U.S. and Canadian broadcast, cable and streaming outlets, including the ABC, CBS, Fox and NBC networks.
The statistic used most often by SU2C is from the American Cancer Society: one out of every two men and one out of every three women will be diagnosed with cancer in their lifetime.
Uplifting: Modern Family lum Sofia Vergara is also playing the role of co-host for the hourlong special that airs on a number of bnroadcasts on Saturday
More star power: Witherspoon also placed a call to Black-ish star Anthony Anderson, who’s also serving as host
Performances: Alabama Shakes frontwoman Brittany Howard is among the artists set to perform for the non-profit’s telethon
Launched in May 2008, Stand Up to Cancer aims to raise awareness and bring about an understanding that everyone is connected to cancer.
Part of its mission is to ‘raise funds to accelerate the pace of groundbreaking translational research that can get new therapies to patients quickly and save lives now.,’ according to its website: standuptocancer.org.
In those 13 years, the non-profit has raised more than $603 million for research that has contributed to federal approvals for nine new cancer therapies and 258 clinical trials.
Make a difference: Stand Up To Cancer will be shown commercial-free on dozens of U.S. and Canadian broadcast, cable and streaming outlets, including ABC, CBS, Fox and NBC