The three-time Grand Slam winner was due to face South Africa’s Lloyd Harris in the first round at Hard Rock Stadium on Wednesday.
However, it was revealed on Tuesday that Murray had been forced to pull out of the ATP Tour Masters 1000 event due to a groin issue.
Speaking to the Miami Herald about his latest problem, Murray was bemused by what he called a “freak” injury.
“I had no issues while training, felt fine, did some gym work Friday, no problem, and then I woke up about 3am, felt pain in the groin – not on the side I had my surgery – and when I got out of bed I struggled quite abit to walk,” he said.
Murray added: “I have no idea what I did. It’s one of those freak things. Each day it has gotten progressively better, but it’s not enough. I have not practised since Friday.
“I am really gutted. This is a place I have done so much training over the years. It’s like my second home. Last time I played here was 2016 and so much has happened.
“Last year, the day before I was supposed to travel here Covid stopped the tennis tour. Miami’s been a place that has given me a lot, but this just wasn’t meant to be.”