The three of them all missed Arsenal’s 0-0 draw with Manchester United on Saturday and they are doubts for tomorrow’s game at Molineux.
Tierney is struggling with a calf issue, while Saka had to pull out of Saturday’s draw due to a problem with his hip.
Aubameyang was absent too as he was quarantining after leaving Arsenal’s first-team bubble to visit his ill mother and Arteta is unsure if he will be back to face Wolves.
“There’s still some things to clear up,” he said. “Maybe yes, maybe no. We don’t know [if he will play against Wolves]. We’re still doing some paperwork at the moment.”
Saka and Tierney are struggling too, with Arteta explaining he will give them as long as possible to prove their fitness.
“We don’t know yet [if they’ll return for Wolves],” he said. “Today we’ve got a training session and they haven’t been able to train with us yet, so I think it will be really difficult for them.
“But I don’t know, we are going to try until the last minute – see how they are feeling.”
In more positive news, Arsenal should have Alexandre Lacazette fit for their trip to Wolves. The striker went off in the final stages of Saturday’s draw against Manchester United after colliding with defender Harry Maguire, but he has recovered.
“We have to follow the protocols, that we have to test him and make an x-ray,” said Arteta.
“He was completely fine after the game, he was fine yesterday and he has slept well. I’m expecting him to be available.”
Arsenal head to Wolves looking to extend their unbeaten run in the Premier League, which currently stands at seven games.
“Obviously we took some pressure off ourselves with the situation we were in the table, but we know there is a long way to go, a lot of points to catch up with the top teams,” said Arteta.
“But we have to go game by game, and if we keep performing in the way we are at the moment, we will be in a good position at the end of the season. But we have to be very consistent to have any chance of achieving any top spot.”