Sunday’s 1-0 defeat to Burnley meant the Gunners has lost four on the spin at home in the league for the first time in 61 years.
The pressure is mounting on manager Mikel Arteta, with the goodwill from last season’s FA Cup triumph having faded and his side down in 15th.
Southampton, by contrast, are in terrific form and head to the Emirates having lost just one of their last ten in the league.
Arsenal 0-1 Burnley, Simon Collings Reports
Arsenal vs Southampton prediction: 1-1 draw
The last thing Arsenal can afford is another defeat and really only a victory will do anything to ease the pressure on Arteta.
Unfortunately for the Spaniard, Saints are in superb form under Ralph Hassenhutl and it would be a surprise if they left the Emirates with nothing.
Date, kick-off time and venue
Arsenal vs Southampton is scheduled for a 6pm kick-off on Wednesday, December 16, 2020.
The game will be played behind-closed-doors at the Emirates Stadium after London was placed under Tier 3 coronavirus restrictions this week.
How to watch Arsenal vs Southampton
Live stream: Amazon Prime subscribers will be able to watch the match online.
Arsenal vs Southampton team news
Arsenal will be without Granit Xhaka who is suspended after being sent off against Burnley, while Hector Bellerin also misses out after racking up his fifth yellow card of the season, but Nicolas Pepe is available after serving his own three-match ban for a red card against Leeds.
Mikel Arteta has no fresh injury concerns from the Burnley defeat but must surely be tempted to make changes to his faltering side, with several young players who have impressed in the Europa League pushing for involvement.
Arsenal predicted XI: Leno; Cedric, Holding, Gabriel, Tierney; Ceballos, Elneny; Pepe, Willock, Saka; Aubameyang.
Arsenal vs Southampton h2h Premier League results
- Arsenal wins: 23
- Draws: 12
- Southampton wins: 7
- Last meeting: Southampton 0-2 Arsenal (June 25, 2020)
Arsenal vs Southampton odds and betting tips (subject to change)
- Arsenal to win: 11/8
- Draw: 5/2
- Southampton to win: 12/5
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