The pair are both suspended after picking up red cards recently and as result they cannot take part in the match at Goodison Park.
In their place, David Luiz is likely to come into the defence and Arteta should stick with Dani Ceballos and Mohamed Elneny in midfield.
Ainsley Maitland-Niles and Bukayo Saka are likely to remain as the wing-backs, but Hector Bellerin is available again after finishing his one-game ban.
In attack, Nicolas Pepe and Pierre-Emerick Aubameyang should keep their places, but Alexandre Lacazette may come in for Eddie Nketiah.
Predicted Arsenal XI (3-4-3): Leno; Holding, Luiz, Tierney; Maitland-Niles, Elneny, Ceballos, Saka; Pepe, Nketiah, Aubameyang.
Today 5.30pm GMT, Sky Sports
Arsenal squad from: Leno, Macey, Runarsson; Bellerin, Cedric, Chambers, Holding, Luiz, Mustafi, Kolasinac, Mari, Tierney, Saliba; Ceballos, Elneny, Maitland-Niles, Saka, Smith Rowe, Willock; Aubameyang, Balogun, Lacazette, Martinelli, Nelson, Nketiah, Pepe and Willian.
Suspended: Gabriel and Xhaka
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