Partey has been nursing a thigh injury, but starts in midfield with Granit Xhaka as the Gunners look for a result against their rivals.
Arteta has been using a back four recently, and it looks like he has stuck with a 4-2-3-1 formation once again.
Gabriel Magalhaes and Kieran Tierney come into the side along with Rob Holding, but David Luiz misses out.
In attack, Bukayo Saka and Pierre-Emerick Aubameyang return – and they could be joined by Alexandre Lacazette and Willian.
Arsenal XI: Leno, Holding, Gabriel, Tierney, Bellerin, Thomas, Xhaka, Saka, Willian, Lacazette, Aubameyang
Subs: Ceballos, Runarsson, Maitland-Niles, Mustafi, Elneny, Willock, Nketiah
Today 4.30pm GMT, Sky Sports
Venue: Tottenham Hotspur Stadium
Arsenal squad from: Leno, Macey, Runarsson; Bellerin, Cedric, Chambers, Gabriel, Holding Luiz, Mari, Mustafi, Saliba Tierney; Azeez, Ceballos, Cottrell, Maitland-Niles, Partey, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Nelson, Nketiah and Lacazette.
Injured: Martinelli (knee).
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