Left-back Kieran Tierney missed Friday’s win over Aston Villa with an ankle problem and is not risked against the Whites as Arsenal assess the issue.
It means the likes of Eddie Nketiah and Gabriel Martinelli start, with Sead Kolasinac at left-back and Emile Smith Rowe keeping his place in midfield.
Midfielders Ainsley Maitland-Niles and Mohamed Elneny both feature, with Cedric Soares are at right-back.
Bernd Leno replaces Aaron Ramsdale in goal, as expected. Rob Holding also comes in at centre-back to partner Ben White.
Arsenal vs Leeds lineups
Arsenal XI: Leno, Cedric, Holding, White, Kolasinac, Maitland-Niles, Elneny, Smith Rowe, Martinelli, Nketiah, Pepe
Arsenal subs: Ramsdale, Tavares, Chambers, Lokonga, Partey, Saka, Salah-Eddine, Lacazette, Balogun
Leeds XI: Meslier, Drameh, Llorente, Struijk, Dallas, Phillips, Forshaw, Roberts, James, Harrison, Rodrigo
Leeds subs: Klaesson, Cooper, Hjelde, Cresswell, Klich, McKinstry, Gelhardt, Summerville, Greenwood