Villa captain Grealish is still struggling with a shin injury and is yet to resume full training at Bodymoor Heat, so is likely to sit out a fourth game in a row.
Matt Cash (hamstring), Kortney Hause (foot) and Wesley (knee) are also sidelined for Dean Smith but all are nearing a return.
As for Wolves, Nuno Espirito Santo has no fresh injuries ahead of their trip to Villa Park after Tuesday’s 4-1 defeat at Manchester City.
Raul Jimenez is continuing his recovery from the fractured skull he suffered in November but is in non-contact training with the squad.
Aston Villa vs Wolves predicted lineups
Villa (4-3-3): Martinez; Elmohamady, Konsa, Mings, Targett; McGinn, Nakamba, Ramsey; Traore, Watkins, El Ghazi
Wolves (3-4-2-1): Patricio; Dendoncker, Coady, Saiss; Semedo, Neves, Moutinho, Castro; Neto, Traore; Jose
Aston Villa provisional squad: Martinez, Steer, Heaton, Mings, Engles, Elmohamady, Targett, Taylor, Konsa, McGinn, Luiz, Barkley, Sanson, Trezeguet, El Ghazi, Ramsey, Nakamba, Davis, Traore, Watkins.
Wolves provisional squad: Patricio, Ruddy, Hoever, Ait-Nouri, Coady, Jonny, Semedo, Saiss, Kilman, Richards, Lonwijk, Neves, Gibbs-White, Vitinha, Moutinho, Dendoncker, Otasowie, Cundle, Neto, Jose, Silva, Traore.
Additional reporting by PA.