But the Bees will be out to recreate their sterling displays at home to Liverpool and Arsenal by claiming another big scalp, with West Ham their latest victim ahead of the international break.
The last time the teams met in the league was 1947 yet this West London derby promises to be a hugely intense affair.
With kick-off at 5.30pm BST, follow all the action from Brentford Community Stadium.
Hello and welcome!
It is a big day in West London as Brentford welcome Chelsea for a juicy Premier League clash.
We will be keeping you abreast of the team news ahead of the 5.30pm kick-off, with live updates from the derby and all the major reaction post-match.