Manchester City have won the competition in all of the last four seasons, and will lie in wait in the third round once clubs have emerged from the early season fixtures
Wayne Rooney’s Derby County will come face-to-face with the Class of 92-owned Salford City in one of the standout ties in the Carabao Cup first round.
Reading take on 2013 winners Swansea in one of the other ties of the round, while newly-relegated Sheffield United host Carlisle and Charlton host AFC Wimbldeon.
Blackpool, newly promoted to the Championship, face a home game with Middlesbrough, while Hull City take on Wigan Athletic.
Birmingham City, the 2011 winners, will host Colchester United.
Manchester City have won the competition in all of the last four seasons, and will lie in wait in the third round once clubs have emerged from the early season fixtures.
Pep Guardiola’s side beat Tottenham Hotspur in last season’s delayed final at Wembley, where defender Aymeric Laporte headed an 82nd minute winner in front of just over 7,500 fans.
It is to be hoped that clubs will be allowed to play matches in front of full stadiums very early into the 2021-22 season, if not at the very beginning, with proof of a double vaccination set to be key to obtaining entry.
The first round draw only includes clubs from Leagues One and Two and 22 of the 24 clubs in this season’s Championship.
Clubs competing in Europe will then enter from the third round.
The Carabao Cup first round draw in full:
Sheffield Wednesday vs Huddersfield Town
Derby County vs Salford City
Hartlepool United vs Crewe Alexandra
Shrewsbury vs Lincoln
Mansfield Town vs Preston North End
Port Vale vs Sunderland
Sheffield United vs Carlisle United
Blackpool vs Middlesbrough
Harrogate Town vs Rochdale
Stoke City vs Fleetwood Town
Walsall vs Doncaster Rovers
Oldham vs Tranmere
Rotherham United vs Accrington Stanley
Barrow vs Scunthorpe
Hull City vs Wigan Athletic
Bolton vs Barnsley
Nottingham Forest vs Bradford City
Blackburn Rovers vs Morecambe
Cambridge United vs Swindon Town
Exeter City vs Wycombe
Crawley vs Gillingham
Burton vs Oxford
Coventry vs Northampton
Ipswich vs Newport
Forest Green vs Bristol City
Reading vs Swansea
Cardiff vs Sutton
Bournemouth vs MK Dons
Bristol Rovers vs Cheltenham
Peterborough vs Plymouth
Leyton Orient vs QPR
Stevenage vs Luton
Millwall vs Portsmouth
Birmingham vs Colchester
Charlton vs Wimbledon