Ziyech had targeted the clash with Mikel Arteta’s struggling side after limping out of the win against Leeds with a strained hamstring at the start of the month.
Callum Hudson-Odoi, who also suffered a similar injury, already returned to the squad for Monday’s game against West Ham.
But Ziyech is set for longer in the treatment room after already missing the start of the season with a knee problem.
Frank Lampard said: “You have to wait to recover. It’s not a long-term concern and we hope to have him back in the next week or so. And hopefully he can offer what he did before because he was offering great things.
“We missed that in a way, but that’s football and it’s what happens when players are playing at high level every two or three days.”
James was rested against West Ham with an ongoing knee issue, while Chilwell hurt his ankle in that game – but both are fit enough to start here.
Chelsea lineup: Mendy, James, Zouma, Thiago Silva, Chilwell, Kante, Kovacic, Mount, Pulisic, Abraham, Werner
Subs: Arrizabalaga, Rudiger, Jorginho, Giroud, Hudson-Odoi, Gilmour, Azpilicueta, Havertz, Emerson Palmieri
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