Havertz is flanked by Mason Mount and Callum Hudson-Odoi at Stamford Bridge, with Christian Pulisic still recovering from an ankle problem.
Werner appeared to strain his hamstring and Thomas Tuchel revealed on Friday that both players would be sidelined for at least Chelsea’s next two matches against Norwich and Southampton.
The Blues make five changes in total to face Norwich, with England defender Reece James fit again and Trevoh Chalobah and Mateo Kovacic also returning to the starting XI, along with Havertz and Hudson-Odoi.
Chelsea vs Norwich lineups
Chelsea XI: Mendy, Chalobah, Thiago Silva, Rudiger, James, Jorginho, Kovacic, Chilwell, Hudson-Odoi, Mount, Havertz
Subs: Arrizabalaga, Alonso, Christensen, Loftus-Cheek, Saul, Barkley, Ziyech, Azpilicueta, Sarr
Norwich XI: Krul, Kabak, Gibson, Hanley, Aarons, Lees-Melou, Normann, McLean, Giannoulis, Sargent, Pukki
Subs: Rupp, Dowell, Rashica, Tzolis, Sorensen, Williams, Gunn, Idah, Omobamidele