However, they have reason to be confident, going into the match on a run of seven consecutive wins over Australia, not losing since that painful 2015 World Cup defeat.
The Aussies come into the match after a tight defeat to Scotland, and go into this Cook Cup contest without a number of key players.
Follow all the action with Standard Sport’s LIVE blog below…
Hello and welcome to Standard Sport’s LIVE coverage as England host Australia at this evening.
Eddie Jones’ side blasted past Tonga last weekend, but they know they face a much sterner test this time.
We’ll have all the build-up ahead of kick-off which comes at 5:30pm GMT, as well as analysis and updates from our man Will Macpherson at Twickenham.