Tyrone Mings is suspended for the game in Warsaw but Southgate has no fresh injuries worries and England are at full strength.
England can take a major step towards qualification for the 2022 World Cup in Qatar with victory in Warsaw but Southgate has warned against complacency – particularly with Robert Lewandowski leading Poland’s attack.
“As a team, we have to recognise that we’re in a good moment and the team are playing well,” he said. “There’s a squad of players, any of whom are more than comfortable coming into the side and playing well when they’re coming into the team.
“But also those moments can be dangerous because if we get any sense of complacency then we’re going into a game where we’ll be really challenged and this is a big opportunity for us.
“We can really take a positive step towards the World Cup if we win in Warsaw, so it’s a high level of motivation, but also guarding against any feeling that we were better than we are.
“We’re having a good run of results because we’re working hard for each other, because without the ball we’re very disciplined and that sets the tone for our game.
“It’s an opportunity, no more no less. We know that to go away from home and win is not easy, not straightforward. Poland also have high motivation, to be able to top the group they probably have to win the game, so it’s a game for everybody to look forward to.”
England team: (4-2-3-1) Pickford; Walker, Stones, Maguire, Shaw; Rice, Phillips; Sterling, Mount, Grealish; Kane.
Wednesday, 7.45pm BST, ITV
Venue: Stadion Narodowy, Warsaw
Referee: Daniel Siebert (GER)