Initial reports suggested an injury to Benzema’s right leg, with his withdrawal precautionary, but further diagnosis will come after the game.
Benzema has been recalled to Didier Deschamps’ squad for the tournament for the first time in five-and-a-half years.
He made his first international appearances since October 2015 in last week’s 3-0 friendly triumph over Wales, starting up front alongside Kylian Mbappe, and did so again against Bulgaria before his 83rd France cap was cut short.
France are in the European Championships’ so-called Group of Death, alongside Germany, Portugal and Hungary.
The world champions begin their campaign against Germany in Munich next Tuesday in what looks one of the group stage’s biggest clashes.