Jose Mourinho’s talisman took a separate knock to each ankle during the first period, though it was the second incident on his left joint that caused the major problem.
It is the latest injury Kane has suffered in recent seasons.
Here is a look at the extent of them and how Spurs coped without him.
Kane first sustained an ankle injury in a 1-0 Premier League win over Sunderland in September 2016 – where he scored the winner. He fell awkwardly in the final few minutes and scans revealed ligament damage. He ended up sitting out 10 Tottenham games, also missing an international break and returned for a 1-1 draw at Arsenal on November 6. Spurs had a mixed time without him, winning the first four games of his absence, including a 2-0 success over Manchester City, but then things went south as they lost two and drew four of the next six – a run of games which saw them knocked out of the EFL Cup and suffer damaging results in their Champions League group campaign.
The England striker suffered a repeat problem in the early stages of the 6-0 FA Cup win at Millwall in March 2017. He tangled with Jake Cooper after getting a shot away and was unable to continue. Fears were that he would be out for a similar period to his absence earlier in the same season but he only missed three Spurs games, all of which resulted in wins. He returned as a substitute against Watford in early April.
Almost one year on from his last problem, Kane went down again and it was a worrying time for both Tottenham and England fans ahead of the World Cup. It looked serious as the striker had to limp off against Bournemouth after being caught trying to turn the ball into the net. However, it was a quickfire recovery from Kane, who only missed one Tottenham game, along with two England matches as he returned for the success at Chelsea. Spurs won their only game without him, in the FA Cup at Swansea.
Another ankle problem for the England captain. He went down at the end of the 1-0 defeat by Manchester United and did not return to action until they played at Burnley nearly six weeks later – returning with a goal. Spurs won five of their seven matches without their talisman, including a 3-0 Champions League win over Borussia Dortmund.
Kane suffered a lateral ligament injury to his left ankle in the Champions League quarter-final first leg against Man City. He would miss nine matches and although Tottenham would win only two of the six league games he missed, they still managed to progress past City and then Ajax without him to reach the Champions League final. He returned to start the showpiece event in Madrid on June 1 but could not stop Liverpool winning 2-0.
Kane had surgery to repair a ruptured tendon in his left hamstring, sustained in the 1-0 Premier League defeat at Southampton on New Year’s Day. He was due to return in April but the first coronavirus lockdown meant he did not play again until June 19.
Kane suffered injuries to both ankles during the 3-1 home defeat to Liverpool. He carried on until half-time, but was replaced at the interval. Jose Mourinho said of his striker: “Two ankles, the first was a bad tackle, it was Thiago, the second one I didn’t know well. But two injuries in both ankles, the second one worst than the first one – a few weeks, I don’t know.
“There are some players you can’t replace. When it happens it happens but I believe we have to fight against it, we cannot do anything else.”