Seven days on from a dire 0-0 draw in the Premier League, it’s United’s turn to host the fierce derby and a place in the FA Cup fifth round is up for grabs.
Edinson Cavani scored against Fulham and should keep his place with Anthony Martial an injury doubt. Behind him will be the usual three of Rashford, Bruno Fernandes and Paul Pogba.
Solskjaer will need to decide who partners Scott McTominay in midfield, while Nemanja Matic an option over Fred.
Luke Shaw has been terrific of late but Alex Telles is pushing for a start. He could line up alongside Harry Maguire, Eric Bailly and Aaron Wan-Bissaka.
Dean Henderson should come in as the cup goalkeeper.
Predicted Manchester United XI (4-2-3-1): Henderson; Wan-Bissaka, Lindelof, Maguire, Telles; McTominay, Matic; Rashford, Fernandes, Pogba; Cavani