Arsenal will also have to cope without defenders David Luiz and Kieran Tierney, who are still struggling with knee issues.
Martin Odegaard, however, could make the squad as he is recovering well from an ankle problem.
“They are all doing really well to be fair, they are a little bit ahead of schedule,” said Mikel Arteta.
“We don’t expect them for Everton I think, we have a doubt with Martin a little bit, let’s see how he is today in training. The rest will be out and get them back in the team as quick as possible.”
Youngster Folarin Balogun, who recently signed a new deal, will hope to make the squad and make his Premier League debut.
Arsenal predicted XI (4-2-3-1): Leno; Chambers, Holding, Mari, Xhaka; Partey, Ceballos; Saka, Smith Rowe, Pepe; Nketiah
Friday 8.00pm GMT, Sky Sports
Arsenal squad from: Leno, Runarsson, Ryan; Bellerin, Cedric, Chambers, Gabriel, Holding, Mari; Ceballos, Elneny, Odegaard, Partey, Saka, Smith Rowe, Xhaka; Balogun, Martinelli, Nelson, Nketiah, Pepe and Willian.
Injured: Aubameyang (malaria), Lacazette (hamstring), Luiz (knee) and Tierney (knee)