The teenager has been struggling with a hamstring issue after limping off during last weekend’s win over Tottenham but he returns in a boost for the Gunners.
Calum Chambers starts at right back and makes only his second Premier League start of the season.
Pablo Mari comes into the team alongside David Luiz at centre-back.
Willian misses out with the calf issue that forced out of Thursday’s defeat to Olympiacos.
Martin Odegaard and Thomas Partey return to the starting line-up after being rested in midweek, while Pierre-Emerick Aubameyang starts.
Emile Smith Rowe and Pepe both start on the bench.
Arsenal line-up: Leno; Chambers, David Luiz, Mari, Tierney; Partey, Xhaka; Saka, Odegaard, Aubameyang; Lacazette.
Subs: Ryan, Cedric, Holding, Gabriel, Elneny, Ceballos, Smith Rowe, Pepe, Martinelli.
Sunday 3.00pm GMT, Sky Sports