Neco Williams and Ryan Williams both start in the back four, with Fabinho and Trent Alexander-Arnold dropping to the bench, while Thiago Alcantara and Curtis Jones are rested in midfield.
Diogo Jota makes his first Premier League start since returning from injury, joining Mo Salah and Xherdan Shaqiri in the forward line as Sadio Mane is another player afforded a rare rest.
Klopp, meanwhile, is without Roberto Firmino because of a minor knock, while Ozan Kabak also misses out after picking up a injury in the defeat to Chelsea in midweek.
Liverpool starting lineup (4-3-3): Alisson, N. Williams, Phillips, R. Williams, Robertson, Wijnaldum, Milner, Keita, Shaqiri, Salah, Jota
Injury list: Henderson, Van Dijk, Gomez, Matip
Doubts: Kabak, Kelleher, Phillips