Given the Europa showpiece comes just three days after United’s trip to the Midlands, Solskjaer will rotate with second place in the League table already assured.
While Dean Henderson appeared to be dropped against Fulham following a shaky display versus Liverpool, the more likely scenario is that Solskjaer was trialling his probable XI against Villarreal last time out at Old Trafford.
David de Gea started against Fulham, and given he is the cup goalkeeper as it stands, he will surely face Villarreal – and that means Henderson should return at Molineux.
As for the rest of the team, it is likely to be all change – though Harry Maguire is out with ankle ligament damage, and it looks unlikely he will be back against Villarreal if he is not a substitute on Sunday at the very least.
Fred and Scott McTominay are both doubts after picking up knocks in the last game, and are unlikely to be risked – and that means Donny van de Beek could get a rare start.
Solskjaer has two main selection issues for the final: if Maguire misses out, either Axel Tuanzebe or Eric Bailly will start alongside Victor Lindelof in central defence.
Given both are injury-prone, Solskjaer could play both at Molineux and hand a Final spot to whoever fares better – or whoever lasts the full game.
The other dilemma comes in attack: Marcus Rashford has lost form and been hampered by injuries during the run-in, losing his spot to Mason Greenwood. However, Greenwood flattered to deceive against Fulham, and a big 90 minites from Rashford here could earn him a start in the Final.
Anthony Martial and Dan James are on the comeback trail, while Phil Jones remains sidelined.
Man Utd predicted XI (4-2-3-1): Henderson; Williams, Tuanzebe, Bailly, Telles; Matic, Fred; Mata, Van de Beek, Amad; Rashford
Injury list: Maguire, Jones
Doubts: Martial, James, McTominay, Fred