Ralf Rangnick will be watching on from the stands, with his work visa not arriving in time to allow him to be in the dugout.
Given Rangnick is widely credited with bringing modern pressing into German football before Jurgen Klopp and Thomas Tuchel raised the game, Ronaldo does not exactly look like a natural fit, but he starts for United.
Harry Maguire, meanwhile, is back from suspension, but Luke Shaw misses out. Paul Pogba, Raphael Varane and Edinson Cavani remain sidelined.
Starting XI: De Gea, Dalot, Lindelof, Maguire, Telles, Fred, McTominay, Fernandes, Sancho, Ronaldo, Rashford
Subs: Henderson, Jones, Bailly, Mata, Van de Beek, Lingard, Amad, Martial, Greenwood