United kicked off the Premier League season with a 5-1 rout of Leeds, but some of the optimism for the new campaign dissipated as they came unstuck with a disappointing 1-1 draw at Southampton.
The Red Devils looked disjointed in that clash on the south coast, but Raphael Varane and Jadon Sancho start this afternoon.
Scott McTominaey misses out having had groin surgery earlier this week and joins goalkeeper Dean Henderson (recovering from coronavirus), full-back Alex Telles (ankle) and striker Marcus Rashford (shoulder), as well as long-term absentee Phil Jones (knee), on the sidelines.
With Edinson Cavani still lacking match fitness and Anthony Martial unimpressive leading the line last time out, Mason Greenwood will play up front with Sancho, Paul Pogba and Bruno Fernandes in support.
Confirmed team news
Wolves: Jose Sa, Kilman, Coady, Saiss, Nelson Semedo, Neves, Joao Moutinho, Marcal, Trincao, Jimenez, Traore
Subs: Hoever, Ait Nouri, Daniel Podence, Boly, Silva, Gibbs-White, Ruddy, Dendoncker, Cundle
Man Utd: de Gea, Wan Bissaka, Varane, Maguire, Shaw, Pogba, Fred, James, Bruno Fernandes, Sancho, Greenwood
Subs: Lindelof, Cavani, Mata, Martial, Lingard, Dalot, Heaton, Matic, van de Beek.
Sunday, 4.30pm BST, Sky Sports
Man Utd squad from: De Gea, Heaton, Grant, Wan-Bissaka, Dalot, Lindelof, Maguire, Bailly, Varane, Shaw, Williams, Matic, Fred, Van De Beek, Pogba, Fernandes, Mata, Lingard, James, Sancho, Diallo, Martial, Greenwood, Cavani.
Out: McTominay (groin), Rashford (shoulder), Telles (ankle), Jones (knee), Henderson (fatigue)