With caretaker Michael Carrick having gone unbeaten during his three games in temporary charge before leaving somewhat surprisingly, Rangnick could make further headway in pushing United towards the top four with a victory this afternoon.
He has shaken off the knock he picked up in the win over Arsenal.
Elsewhere, United remain without key centre-back Raphael Varane, but his recovery from a thigh injury is said to be progressing well.
Paul Pogba also remains sidelined, while the likes of Luke Shaw, Aaron Wan-Bissaka and Nemanja Matic all miss out on the starting line-up, as does Edinson Cavani who is still carrying an injury.
Man United XI: De Gea, Dalot, Maguire, Lindelof, Telles, Fred, McTominay, Fernandes, Rashford, Sancho, Ronaldo
Subs: Henderson, Bailly, Jones, Wan-Bissaka, Elanga, Matic, van de Beek, Mata, Greenwood