A 4-0 first-leg thumping leaves United with one foot in the last-16 stage.
Donny van de Beek and Edinson Cavani join Paul Pogba and Scott McTominay on the sidelines, meaning the likes of Brandon Williams and Juan Mata should be afforded minutes.
Harry Maguire is a booking away from suspension so is likely not to be risked, meaning, Axel Tuanzebe could come in at centre-back.
Fans will want to see Amad Diallo start after making his debut last week, but Solskjaer said the new signing – and Shola Shoretire – could come off the bench.
Manchester United predicted XI (4-2-3-1): Henderson; Williams, Tuanzebe, Bailly, Telles; Fred, Matic; James, Mata, Rashford; Greenwood
Injuries: Donny van de Beek, Edinson Cavani, Paul Pogba, Scott McTominay, Phil Jones