Sergio Busquets and Diego Llorente tested positive earlier in the week for Spain, while Dejan Kulusevski and Mattias Svanberg were struck down for the Swedes.
The Spain squad have since been vaccinated, though coach Luis Enrique is concerned by the effects the jab could have on his players on Monday.
Here is how we predict the two sides will shape up…
Spain vs Sweden predicted lineups
Spain XI: Simon; Azpilicueta, P Torres, Laporte, Alba; Thiago, Rodri, Pedri; F Torres, Morata, Oyarzabal
Sweden XI: Olsen; Lustig, Lindelof, Danielson, Augustinsson; Claesson, Ekdal, Olsson, Forsberg; Berg, Isak
Goalkeepers: David de Gea, Robert Sanchez, Unai Simon
Defenders: Aymeric Laporte, Jose Gaya, Jordi Alba, Pau Torres, Eric Garcia, Diego Llorente, Cesar Azpilicueta
Midfielders: Marcos Llorente, Sergio Busquets, Rodri, Pedri, Thiago, Koke, Fabian
Forwards: Dani Olmo, Mikel Oyarzabal, Gerard Moreno, Alvaro Morata, Ferran Torres, Adama Traore, Pablo Sarabia
Goalkeepers: Karl-Johan Johnsson, Kristoffer Nordfeldt, Robin Olsen
Defenders: Emil Krafth, Victor Lindelof, Marcus Danielson, Martin Olsson, Ludwig Augustinsson, Pontus Jansson, Filip Helander, Mikael Lustig, Andreas Granqvist
Midfielders: Emil Forsberg, Ken Sema, Viktor Claesson, Dejan Kulusevski, Sebastian Larsson, Albin Ekdal, Kristoffer Olsson, Jens-Lys Cajuste, Mattias Svanberg, Gustav Svensson
Forwards: Marcus Berg, Alexander Isak, Robin Quaison, Jordan Larsson