Serge Aurier has missed the last two matches through injury and will not be fit enough to return in Hungary, with Matt Doherty or Tanganga also able to cover at right-back.
Gareth Bale’s bright cameo at the Etihad Stadium should be enough to earn him a rare start, while Dele Alli is also pushing for inclusion after substitute appearances in the last two games.
Harry Kane will be needed in Sunday’s crucial League match against West Ham but he is likely to start, with Carlos Vinicius and young striker Dane Scarlett set to be among the subs.
Young defenders Dennis Cirkin, a left-back, and Marcel Laviniar, as well as midfielder Jamie Bowden, have also made the trip.
Joe Rodon is ineligible, while Giovani Lo Celso remains sidelined with a hamstring injury.
Predicted Tottenham XI (4-2-3-1): Lloris; Doherty, Alderweireld, Dier, Tanganga; Sissoko, Winks; Bale, Dele, Bergwijn; Kane.
Injured: Reguilon (hamstring), Lo Celso (hamstring), Aurier
Spurs squad from: Lloris, Hart, Whiteman,, Doherty, Laviniar, Alderweireld, Dier, Sanchez, Davies, Cirkin, Tanganga, Hojbjerg, Sissoko, Winks, Dele, Ndombele, Lucas, Bowden, Lamela, Bergwijn, Son, Bale, Kane, Vinicius, Scarlett.
Venue: Puskas Arena, Budapest, 17.55, BT Sport