Harry Winks and Japhet Tanganga come into the team in place of the suspended Oliver Skipp and the injured Cristian Romero.
Pierre-Emile Hojbjerg has been passed fit and starts after missing both of Denmark’s World Cup qualifiers over the international break.
Romero misses the match with a hamstring strain picked up in Argentina’s 0-0 draw with Brazil on Tuesday night. Skipp is serving his one-match ban.
Leeds are without the injured Raphinha in a major blow for Marcelo Bielsa.
Tottenham confirmed XI: Lloris, Dier, Tanganga, Davies, Reguilon, Royal, Winks, Hojbjerg, Moura, Son, Kane.
Subs: Gollini, Doherty, Sanchez, Gil, Rodon, Sessegnon, Alli, Bergwijn, Ndombele.
Leeds confirmed XI: Meslier, Forshaw, Cooper, Llorente, Struijk, Dallas, Harrison, Phillips, Klich, Gelhardt, James.
Subs: Klaesson, Firpo, Roberts, Cresswell, Drameh, McKinstry, Greenwood, McCarron, Jenkins.
Date: Sunday, November 21, 202,4:30pm GMT, live on Sky Sports
Venue: Tottenham Hotspur Stadium