The Spurs manager revealed on Tuesday that he is still having to manage Gareth Bale’s minutes, and the Welshman would himself on the bench and be saved for the crucial home match against Burnley on Sunday after he changed the match against West Ham as a substitute.
Joe Hart comes in between the sticks after club captain Hugo Lloris played the first leg, while Toby Alderweireld, who Mourinho has already confirmed will start, is alongside Eric Dier.
Steven Bergwijn is pushing for minutes, having slipped behind Lucas Moura and Erik Lamela in the pecking order for League games, and starts.
Giovani Lo Celso is back in training but remains unavailable, along with the injured Serge Aurier and ineligible Joe Rodon.
A number of youngsters including Dane Scarlett and Jamie Bowden are on the bench.
Starting XI: Hart, Doherty, Alderweireld, Dier, Davies, Sissoko, Winks, Lamela, Dele, Bergwijn, Vinicius.
Subs: Lloris, Tanganga, Reguilon, Lavinier, Markanday, John, Ndombele, Bale, Lucas, Kane, Son, Scarlett
Venue: Tottenham Hotspur Stadium, Wednesday 24 February, 17.00, BT Sport
Spurs from: Lloris, Hart, Whiteman, Doherty, Tanganga, Davies, Reguilon, Cirkin, Alderweireld, Dier, Sanchez, Lavinier, Winks, Sissoko, Ndombele, Dele, Devine, Hojbjerg, Bowden, Bergwijn, Lamela, Lucas, Bale, Kane, Vinicius, Son, Scarlett.
Injury list: Lo Celso, Aurier