The midfielder has been struggling with a hamstring issue, but could be ready for the second leg of the Gunners’ last-32 tie in Athens.
The defence is likely to show one change from Rome last week, with Kieran Tierney coming in for Cedric Soares.
In attack, Mikel Arteta has some decisions to make. Martin Odegaard has started the last three games so he could now drop out.
That would see Emile Smith Rowe start as the No10, with Alexandre Lacazette leading the line and Pierre-Emerick Aubameyang playing out left.
Arsenal likely XI (4-2-3-1): Leno; Bellerin, Luiz, Gabriel, Tierney; Ceballos, Xhaka; Saka, Smith Rowe, Aubameyang; Lacazette
Thursday 5.55pm GMT, BT Sport
Venue: Stadio Georgios Karaiskakis
Arsenal squad from: Leno, Ryan; Bellerin, Cedric, Chambers, Gabriel, Luiz, Mari, Tierney; Ceballos, Elneny, Odegaard, Partey, Saka, Smith Rowe, Xhaka; Aubameyang, Balogun, Lacazette, Martinelli, Nelson, Nketiah, Pepe and Willian.
Doubts: Partey (hamstring)
Injured: Holding (concussion protocols)