A number of first-team players should be rested for the third round tie at Emirates Stadium on Saturday, with those in need of minutes coming in.
The likes of Calum Chambers and David Luiz should come into the defence, while Cedric Soares and Shkodran Mustafi are candidates to return too.
Bernd Leno could start ahead of Alex Runarsson in goal given the latter struggled during the Carabao Cup quarter-final defeat to Manchester City last month.
In midfield, Ainsley Maitland-Niles and Mohamed Elneny are primed to come in, with Joe Willock playing as a No10.
Out wide, Nicolas Pepe and Willian will hope to play – but Reiss Nelson is back fit and pushing to start. Eddie Nketiah should lead the line.
Arsenal predicted XI (4-2-3-1): Leno; Mustafi, Chambers, Luiz, Cedric; Maitland-Niles, Elneny; Pepe, Willock, Willian; Nketiah.
Arsenal squad from: Leno, Macey, Runarsson; Bellerin, Cedric, Chambers, Holding, Luiz, Mustafi, Kolasinac, Mari, Tierney; Ceballos, Elneny, Maitland-Niles, Partey, Saka, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Lacazette, Martinelli, Nelson, Nketiah, Pepe and Willian.
Doubts: Gabriel (Covid-19).