The Spaniard has been using a back four recently, but he may revert to a three given Spurs’ attacking talent.
Either way the likes of Gabriel Magalhaes and Kieran Tierney will come into the side, while David Luiz and Rob Holding are pushing to join them.
Dani Ceballos and Granit Xhaka are the favourites to start in central midfield after being rested on Thursday against Rapid Vienna, but Mohamed Elneny and Joe Willock are pushing them.
In attack, Bukayo Saka and Pierre-Emerick Aubameyang will return and they could be joined by Alexandre Lacazette.
Arsenal predicted line-up (3-4-3): Leno; Holding, Gabriel, Tierney; Bellerin, Ceballos, Xhaka, Saka; Willian, Lacazette, Aubameyang.
Venue: Tottenham Hotspur Stadium
Arsenal squad from: Leno, Macey, Runarsson; Bellerin, Cedric, Chambers, Gabriel, Holding Luiz, Mari, Mustafi, Saliba Tierney; Azeez, Ceballos, Cottrell, Maitland-Niles, Partey, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Nelson, Nketiah, Lacazette and Pepe.
Doubts: Luiz (head) and Partey (thigh).
Injured: Martinelli (knee).
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