The Spaniard has been using a back four recently, but he may revert to a three-man defence this afternoon given Spurs’ attacking talent.
Either way the likes of Gabriel Magalhaes and Kieran Tierney will come into the side, while David Luiz and Rob Holding are pushing to join them.
Dani Ceballos and Granit Xhaka are the favourites to start in central midfield after being rested on Thursday against Rapid Vienna, but Mohamed Elneny and Joe Willock are pushing them.
In attack, Bukayo Saka and Pierre-Emerick Aubameyang will return and they could be joined by Alexandre Lacazette.
Arsenal predicted line-up (3-4-3): Leno; Holding, Gabriel, Tierney; Bellerin, Ceballos, Xhaka, Saka; Willian, Lacazette, Aubameyang.
Today 4.30pm GMT, Sky Sports
Venue: Tottenham Hotspur Stadium
Arsenal squad from: Leno, Macey, Runarsson; Bellerin, Cedric, Chambers, Gabriel, Holding Luiz, Mari, Mustafi, Saliba Tierney; Azeez, Ceballos, Cottrell, Maitland-Niles, Partey, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Nelson, Nketiah and Lacazette.
Doubts: Luiz (head) and Partey (thigh).
Injured: Martinelli (knee).
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