Left-back Kieran Tierney missed Friday’s win over Aston Villa with an ankle problem and he is unlikely to be risked against Leeds as Arsenal assess the issue.
It means the likes of Eddie Nketiah and Gabriel Martinelli should start, while Nuno Tavares is likely to keep his place at left-back.
Midfielders Ainsley Maitland-Niles and Mohamed Elneny could feature in the fourth round tie against Leeds, while Calum Chambers and Cedric Soares are fighting to come in at right-back.
Bernd Leno is expected to replace Aaron Ramsdale in goal. Centre-backs Pablo Mari and Rob Holding could come into the starting XI too for the game at Emirates Stadium.
Arsenal likely XI (4-2-3-1): Leno; Cedric, Holding, Mari, Tavares; Elneny, Maitland-Niles; Pepe, Odegaard, Martinelli; Nketiah.
Tuesday 7.45pm GMT, Sky Sports
Arsenal squad from: Leno, Ramsdale, Okonkwo; Cedric, Chambers, Gabriel, Holding, Kolasinac, Mari, Tavares, Tierney, Tomiyasu, White; Elneny, Lokonga, Maitland-Niles, Odegaard, Partey, Saka, Smith Rowe; Aubameyang, Balogun, Lacazette, Martinelli, Nketiah and Pepe.