The manager made 11 changes for the 4-0 win over the minnows last month, although England did not double their lead until after Harry Kane and Jack Grealish were introduced from the bench.
With Reece James and Trent Alexander-Arnold ruled out, Kieran Trippier could start at right-back, while James Ward-Prowse and Jordan Henderson may earn recalls in the midfield.
Jesse Lingard was England’s standout player in the win over Andorra at Wembley, scoring twice, and is again in line to start, while Tammy Abraham could earn an immediate recall after returning to the squad.
The likes of Kane, Grealish, Raheem Sterling, Kyle Walker, Luke Shaw and Declan Rice are likely to be saved for the trickier test against Hungary next week, particularly with Andorra’s plastic pitch set to be unfamiliar for Southgate’s players.
England XI (probable 4-2-3-1): Ramsdale; Trippier, Stones, Mings, Chilwell; Henderson, Ward-Prowse; Lingard, Mount, Saka; Abraham.