Despite their comfortable win on Sunday, which allowed them to take their foot off the gas for the final half hour, Liverpool are set to recall several fringe players for the trip to Deepdale.
Divock Origi, Conor Bradley and Alex Oxlade-Chamberlain were among those who started in the previous round’s 3-0 win at Norwich and could return on Wednesday.
Naby Keita is set to miss out after being taken off on a stretcher in the win over United while Harvey Elliott (ankle) and Thiago Alcantara (calf) are unavailable. Caoimhin Kelleher (illness) and James Milner (hamstring) are doubts.
Predicted Liverpool XI: Adrian; Bradley, Gomez, Matip, Tsimikas; Jones, Henderson, Oxlade-Chamberlain; Minamino, Mane, Origi.