City are looking to win the trophy for the fourth season in a row and face an Arsenal side never in a worse state during Pep Guardiola’s time in England.
Aguero sat out the win over Southampton as Ferran Torres led the line in front of Raheem Sterling, Kevin De Bruyne and Bernardo Silva.
It will be a similiar front four on Tuesday, even if Aguero is not fit, with Phil Foden looking for a start.
Elsewhere, Nathan Ake and Benjamin Mendy will also be hoping for a start after watching from the sidelines at St Mary’s.
Predicted Manchester City XI (4-2-3-1): Steffen; Cancelo, Stones, Ake, Mendy; Fernandinho, Gundogan; Mahrez, Foden, Torres; Aguero
Kick-off: Tuesday 8pm GMT, Sky Sports
TV and stream: Sky Sports
Manchester City squad from: Ederson, Steffen, Walker, Cancelo, Stones, Dias, Laporte, Ake, Mendy, Gundogan, Rodri, Fernandinho, De Bruyne, Silva, Sterling, Foden, Mahrez, Torres, Aguero, Jesus.
Doubts: Gabriel Jesus, Aymeric Laporte, Sergio Aguero