The likes of Kevin de Bruyne, Riyad Mahrez and Aymeric Laporte all sat out the draw against Porto which saw City confirmed as Champions League group winners.
Gabriel Jesus came on as a substitute in that game but is likely to lead the line here with Sergio Aguero still an injury doubt.
Nathan Ake returned to the matchday squad in Portugal, while Benjamin Mendy was also rested, meaning Guardiola has plenty of defensive options ahead of the Etihad contest.
Mahrez is likely to return on the wing having scored a terrific hat-trick in last weekend’s thumping win over Burnley.
Man City predicted line-up (4-3-3): Ederson; Walker, Laporte, Dias, Mendy; Gundogan, Rodri, De Bruyne; Mahrez, Torres, Jesus.
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