City are looking to win the competition for the fourth time in a row, and sixth time in eight years, and will reach another final with victory at Old Trafford on Wednesday.
As many as six first-team players have been sidelined with Covid-19, leading to goalkeeper Zack Steffen making his Premier League debut in the 3-1 win at Chelsea.
Gabriel Jesus and Kyle Walker will need a negative test to be in contention after served 10 days of self-isolation.
Steffen should keep his place, while Benjamin Mendy could start despite breaking Covid rules.
Phil Foden scored one and assisted another at Stamford Bridge and should again line up against United.
Ilkay Gundogan will be assessed after taking a knock against Chelsea. Nathan Ake failed a late fitness test ahead of the weekend, so remains a doubt.
Manchester City predicted XI (4-3-3): Steffen, Cancelo, Stones, Dias, Zinchencko, Fernandinho, Rodri, De Bruyne, Mahrez, Sterling, Foden