Walker, Jesus and two other members of City staff have contracted Covid-19, with the duo now set to miss trips to Everton and Chelsea, as well as the Newcastle clash.
Having made several changes for the Carabao Cup win over Arsenal, Guardiola can call on some rested stars this evening.
Raheem Sterling, Ederson and Ilkay Gundogan were among those not called upon from the substitutes’ bench at the Emirates Stadium, while Kevin de Bruyne was left out of the squad completely.
Guardiola is particularly spoilt for choice at centre-back, with his defence in form and the back-in-favour John Stones expected to return – though Eric Garcia is out.
Sergio Aguero has been eased back into action since his return from injury and came on as a substitute against Arsenal.
That would have been likely once again versus Newcastle, but Guardiola now faces a choice over whether to risk Aguero, or opt for Ferran Torres in a striker role.
Man City predicted XI (4-3-3): Ederson; Cancelo, Stones, Dias, Mendy; Gundogan, Rodri, De Bruyne; Sterling, Torres, Mahrez.
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