Aymeric Laporte, John Stones and Rodri have returned to training this week after injury issues but the trio all face late fitness tests.
Speaking on Friday, City manager Pep Guardiola said: “We still have a few injuries.
“Some of them came back a little bit in training and we will decide if they can play or not… we need to see how they react, tomorrow we will see.”
Nathan Ake faces a tough test up against Chelsea striker Romelu Lukaku, who has scored four goals since his £97.5million return to Stamford Bridge over the summer.
Manchester City predicted lineup: 4-1-4-1: Ederson; Walker, Dias, Ake, Cancelo; Fernandinho, Mahrez, De Bruyne, Foden, Grealish; Sterling.