Aaron-Wan Bissaka and Scott McTominay are injured, meaning Nemanja Matic and Brandon Williams starting. Luke Shaw is also a doubt, and could be rested with Alex Telles coming in.
Dean Henderson is expected to take his place in goal despite a howler against Sheffield United.
Elsewhere, Edinson Cavani should start as he awaits a possible three-match ban in the New Year, with Juan Mata and Donny van de Beek also both pushing for a place.
Mason Greenwood will be hoping to feature and improve upon a stop-start season so far, with Eric Bailly looking to stake a claim moving forwards.
Predicted Manchester United XI: Henderson; Williams, Bailly, Maguire, Telles; Matic, Pogba, Mata, Van de Beek; Greenwood, Cavani
Kick-off: Thursday 8pm GMT, Sky Sports
TV and stream: Sky Sports
Manchester United squad from: De Gea, Henderson, Grant, Wan-Bissaka, Fosu-Mensah, Maguire, Tuanzebe, Lindelof, Shaw, Williams, Pogba, McTominay, Fernandes, Fred, Matic, Van De Beek, James, Pellistri, Mata, Greenwood, Rashford, Cavani, Ighalo.
Injured: Jones, Rojo, McTominay, Wan-Bissaka