Edinson Cavani will be assessed ahead of kick-off but it remains to be seen if Ole Gunnar Solskjaer opts to be patience with the striker ahead of the traditionally hectic festive fixture schedule.
Elsewhere, a muscle concern continues to rule Phil Jones out of action, with a return the other side of Christmas more likely.
The Blades have just one point to their name after 12 games, a wretched run of form which is in stark contrast it this time last year when they were flirting with the top four.
Predicted Manchester United XI (4-3-3): De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Fred, Fernandes, Greenwood, Martial, Rashford
Solskjaer tells Paul Pogba’s agent: Football is about teams not individuals
Sheffield United vs Manchester United, Thursday December 17, 8pm GMT
TV and stream details: Amazon Prime
Injured: Phil Jones (muscle)
Doubtful: Edinson Cavani (knock)
Manchester United squad from: De Gea, Henderson, Grant, Wan-Bissaka, Fosu-Mensah, Maguire, Tuanzebe, Lindelof, Shaw, Williams, Pogba, McTominay, Fernandes, Fred, Matic, Van De Beek, James, Pellistri, Mata, Greenwood, Rashford, Cavani, Ighalo.
Last meeting: Manchester United 3-0 Sheffield United