Edinson Cavani is set to miss the game with his fitness under continual assessment and Ole Gunnar Solskjaer likely to be patient with the striker ahead of the traditionally hectic festive fixture schedule.
“Of course we have to be mindful of little strains and niggles, and decisions have to be made,” said Solskjaer on Wednesday, whose side face six games in 16 days.
“From the kick-off of Sheffield United to kick-off (against Aston Villa on New Year’s Day) it’s 15 times 24 hours, so it’s going to be very tight.
“Edinson has done well in his rehab. Still have to make a decision if we should risk him because it is a risk, a little bit to him, too early, so I doubt him to be available for me to pick tomorrow.”
Elsewhere, a muscle concern continues to rule Phil Jones out of action, with a return the other side of Christmas more likely, and Marcos Rojo remains out meaning the defender will not have represented United in 2020.
“Marcos has just felt a niggle in his calf again,” the United boss said of the defender, who spent a period on loan at Estudiantes but was registered for this Premier League season.
“He’s worked really hard to come back. He played a game with the reserves, got a knock there. Worked really hard again and then felt something, so he’s hopefully back in January, Marcos.
“Phil should be ready by January and Sergio (Romero) has been training hard as well.”
The Blades have just one point to their name after 12 games, a wretched run of form which is in stark contrast it this time last year when they were flirting with the top four.
Predicted Manchester United XI (4-3-3): De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Fred, Fernandes, Greenwood, Martial, Rashford
Ole Gunnar Solskjaer on return of Dean Henderson
Sheffield United vs Manchester United, Thursday December 17, 8pm GMT
Injured: Phil Jones (muscle)
Doubtful: Edinson Cavani (knock)
Manchester United squad from: De Gea, Henderson, Grant, Wan-Bissaka, Fosu-Mensah, Lindelof, Maguire, Mengi, Tuanzebe, Telles, Shaw, Williams, Fred, Pogba, McTominay, Fernandes, Matic, Van De Beek, Lingard, James, Mata, Ighalo, Martial, Rashford.
Last meeting: Manchester United 3-0 Sheffield United
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