Otherwise, Mourinho is likely to stick with the same side that beat West Brom before the international break, provided everyone comes through Friday afternoon’s training session unscathed.
Mourinho may be tempted to start with Giovani Lo Celso in place of Gareth Bale to pack the midfield but the Weslhman feels a more likely pick, adding directness on the counter-attack which will be vital to the way Spurs are likely to play.
Harry Winks is a doubt after returning from England duty with a “small problem” while Erik Lamela remains sidelined with an achilles injury.
Heung-min Son has twice tested negative for Covid after an outbreak in the South Korea camp last week, while Steven Bergwijn is fit after pulling out of the Netherlands squad at the start of last week.
Tottenham predicted lineup (4-3-3): Lloris; Aurier, Alderweireld, Dier, Reguilon; Hojbjerg, Sissoko, Ndombele; Son, Kane, Bale.
FPL gameweek 9 tips: Hakim Ziyech in demand
Tottenham squad from: Lloris, Hart, Gazzaniga, Doherty, Aurier, Reguilon, Davies, Rodon, Alderweireld, Dier, Tanganga, Sanchez, Gedson, Winks, Sissoko, Hojbjerg, Dele, Clarke, Lo Celso, Ndombele, Bale, Lucas, Lamela, Bergwijn, Kane, Vinicius.
Injured: Lamela (achilles), Doherty (positive Covid test)
Tottenham vs Manchester City, Saturday 21 November, 17.30. Sky Sports
Venue: The Tottenham Hotspur Stadium
Last meeting: Spurs 2-0 Man City