Alderweireld missed the game against Chelsea with a groin strain but returned to training this week.
If he does not make it, Joe Rodon should deputise as he did against Chelsea, while Kane is expected to play after an unspecified problem ruled him out on Thursday.
Carlos Vinicius is a doubt, while Erik Lamela is expected to remain sidelined.
Tottenham predicted lineup (4-3-3): Lloris; Aurier, Alderweireld, Dier, Reguilon; Hojbjerg, Sissoko, Ndombele; Son, Bergwijn, Kane.
Today 4.30pm GMT, Sky Sports
Venue: Tottenham Hotspur Stadium
Tottenham squad from: Lloris, Hart, Gazzaniga, Whiteman, Doherty, Aurier, Rodon, Alderweireld, Cirkin, Davies, Reguilon, Dier, Tanganga, Sanchez, Winks, Sissoko, Hojbjerg, Dele, Clarke, Lo Celso, White, Ndombele, Bale, Lucas, Son, Lamela, Bergwijn, Scarlett, Vinicius, Kane.
Doubts: Alderweireld (groin), Kane, Reguilon, Vinicius (unspecified)
Injured: Lamela (achilles)
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League.
Terms: Min £10 Same Game Multi bet on any EPL match this Fri- Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.