Heung-min Son has shaken off any injury fears, so should start in a forward line also boosting Steven Bergwijn, who has impressed in two games this term.
Dele Alli can expect to be in a deeper role, likely alongside both Oliver Skipp and Pierre-Emile Hojbjerg.
Joe Rodon (quad) misses out and record signing Tanguy Ndombele is still not being considered by Nuno.
Moussa Sissoko has now joined Watford from Spurs on a two-year deal, but will not face his old team today.
Tottenham predicted XI (4-3-3): Lloris; Tanganga, Dier, Sanchez, Reguilon; Skipp, Hojbjerg, Dele; Son, Kane, Bergwijn
Today, 2pm BST, Sky Sports
Venue: Tottenham Hotspur Stadium
Tottenham squad from: Lloris, Gollini, Tanganga, Doherty, Sanchez, Dier, Romero, Reguilon, Davies, Sissoko, Skipp, Hojbjerg, Lo Celso, Alli, Bergwijn, Moura, Gil, Kane, Son.