The Hammers have won in Europe and the Carabao Cup in recent weeks but have two draws and a defeat in their last three League outings.
Ryan Fredericks and Manuel Lanzini both hobbled off after treatment at Old Trafford in midweek, and Fredericks will not be available on Saturday.
“Fredericks is the only player we have major concerns over,” said Moyes. “He felt his groin and he won’t be fit for this game.”
Moyes has a decision to make in goal after Alphonse Areola made a fine debut in the League Cup, making a string of key saves as he kept a clean sheet.
Lukasz Fabianski has been his No1 in the Premier League and Europe but is under pressure now.
West Ham predicted XI (4-2-3-1): Fabianski; Coufal, Zouma, Ogbonna, Cresswell; Rice, Soucek; Bowen, Benrahma, Fornals; Antonio
West Ham squad from: Fabianski, Martin, Randolph, Areola, Diop, Dawson, Ogbonna, Zouma, Baptise, Coufal, Johnson, Cresswell, Masuaku, Noble, Rice, Kral, Soucek, Fornals, Yarmolenko, Vlasic, Benrahma, Bowen, Antonio
Injured: Fredericks (groin)