It is hoped Tierney can return after missing Tuesday’s win over Southampton, but Partey and Smith Rowe limped off in that game.
They need to be assessed ahead of Manchester United, while Ceballos and Mari are only just returning to training following calf issues.
Arsenal captain Pierre-Emerick Aubameyang is also a doubt for Saturday’s game. The forward has missed the last two matches due to his mother being in ill health.
He is now back home but must return a negative test for Covid-19 and be in the right mental state for Mikel Arteta to pick him.
New signing Martin Odegaard could make the squad, but it appears unlikely he will go straight into the starting XI.
Arsenal likely XI: Leno; Cedric, Holding, Luiz, Tierney; Partey, Xhaka; Saka, Smith Rowe, Pepe; Lacazette
Saturday 5.30pm GMT, Sky Sports
Arsenal squad from: Leno, Runarsson; Bellerin, Cedric, Chambers, Gabriel, Holding, Luiz, Mustafi, Mari, Tierney; Ceballos, Elneny, Maitland-Niles, Odegaard, Partey, Saka, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Lacazette, Martinelli, Nelson, Nketiah, Pepe and Willian.
Doubts: Aubameyang (personal reasons), Ceballos (calf), Mari (calf), Partey (undisclosed), Smith Rowe (undisclosed), Tierney (calf).